Mark Emberton is Professor of Interventional Oncology within the Division of Surgery and Dean of the Faculty of Medical Science at University College London. He is clinically active and holds the position of Honorary Consultant Urologist at University College London Hospitals NHS Trust where he works as a specialist in prostate cancer. His academic work has focused on developing novel diagnostic strategies and new therapies for men with prostate cancer. His research has resulted in the transformation of both the diagnostic and therapeutic pathways. These have been incorporated into international guidelines. He has published over 500 peer review papers, holds a large grant portfolio, and lectures widely around the world and holds international honorary professorships. He is a founding Pioneer of the charity Prostate Cancer UK.

Dr. Barentsz has had an impressive career, starting as an MD in 1980 and obtaining his research PhD in 1990 He has been a trailblazing professor of radiology since 1998 and recently works at the Division of Medical Imaging at the Andros Clinics. His groundbreaking research has left an indelible mark on the field, specifically through the implementation of PI-RADS, which has become the gold standard for prostate MRI worldwide. His influential '4M' paper and other publications have significantly influenced European and Dutch prostate cancer guidelines, now recommending prostate MRI prior to biopsy. Furthermore, Dr. Barentsz's innovative work has sparked a resurgence in ferumoxtran-10 MRI, utilizing dextran-coated iron nanoparticles as an MRI contrast agent to detect 2mm lymph node micro-metastases. This cutting-edge technology is currently undergoing a marketing approval trial in Germany, Switzerland, and The Netherlands, poised to revolutionize the field of medical imaging. Please visit www.mri-prostate-barentsz.nl for Dr. Barentsz biography

Dr. Arvin George is a urologic surgeon specializing in the diagnosis and management of genitourinary cancers. He currently serves as an Associate Professor of Urology and Director of Prostate Cancer Programs at the Johns Hopkins School of Medicine. After obtaining his medical degree from the Royal College of Surgeons in Ireland, he completed his Urology Residency at the Smith Institute for Urology, Hofstra North Shore-LIJ School of Medicine. He also completed his Endourology fellowship in New York gaining additional subspecialty expertise in robotic, laparoscopic, and percutaneous surgery. Subsequently, he completed a Urologic Oncology fellowship at the National Cancer Institute, National Institutes of Health. Dr. George’s clinical practice includes both surgical and non-operative management of prostate, kidney, and upper tract urothelial cancers. His research interests include minimally invasive and image-guided treatments, functional prostate imaging and focal therapy for prostate cancer. Dr. George’s research focuses on the use of prostate MRI, MR/Ultrasound fusion-guided prostate biopsy, and focal therapy for prostate cancer. His research aims to identify appropriate use for imaging in diagnosis, risk stratification, and management of prostate cancer including active surveillance and selection/treatment of patients with novel focal therapy modalities.

Dr. Eric Barret is a urological surgeon at the Montsouris Institute in Paris, France. He is a recognized expert in minimally invasive techniques for the treatment of urological cancer, and particularly prostate cancer. In addition to extensive experience in robotic surgery, he is engaged in improving the management of localized prostate cancer, and for selected patients offers innovative, less invasive therapeutic approaches such as focal therapy. He has been involved in a number of studies in this field, including evaluating the different energy sources for focal approach such as HIFU, cryotherapy, vascular targeted photodynamic therapy and irreversible electroporation. In addition to these clinical activities, Dr. Barret is an active academic urologist and writer, with many international publications to his credit. He chairs the Ablative Group of the EAU-Section of EndoUro Technology (ESEUT) and he is involved in ongoing collaborations in urological oncology and minimally invasive surgery.

Prof. Dr. Jurgen Fütterer is an interventional radiologist and full professor at both the Department of Medical Imaging at Radboud University Medical Center (Radboudumc) and the Robotics and Mechatronics group at the University of Twente. He specializes in MRI-guided interventions and focal therapy for prostate cancer. At Radboudumc, he leads the Minimally Invasive Image-Guided Interventions Center (MAGIC), a research group he founded in 2012 that focuses on advancing image-guided oncological treatments.

Francesco Giganti is Associate Professor of Radiology at University College London and Consultant Radiologist at University College London Hospital. After his training in Italy, he moved to London, UK, where he obtained his PhD in prostate MRI at University College London. Francesco’s main area of expertise is genitourinary imaging, with a specific interest in prostate MRI during active surveillance (PRECISE score), prostate image quality (PI-QUAL score) and prostate MRI after focal treatment (PI-FAB score). He is an expert in teaching prostate MRI for radiologists and urologists, and part of the team commissioned by European Association of Urology to deliver Europe- wide training courses. He is currently the chair of the ESUR Prostate MRI working group and a member of the PI-RADS steering committee.

Background Mr Taimur T. Shah is a clinical senior lecturer and consultant urologist at Imperial College London (ICL). He has a sub-specialist interest in prostate cancer diagnostics, imaging, robotic surgery, focal therapy (high intensity focused ultrasound and cryotherapy) for prostate cancer and minimally invasive treatments for benign prostatic hyperplasia (BPH). He has published extensively in peer- reviewed journals within these fields and been invited to give presentations nationally and internationally. Mr Shah qualified from University College London (UCL) where he was also awarded a First-Class Honours degree in molecular medicine. He subsequently completed his urological training in the London Deanery rotating through the Charing Cross Hospital, The Royal Marsden Hospital, Barnet and Chase Farm Hospitals and the Whittington Hospital. He subsequently undertook a uro-oncology fellowship in robotic surgery at Guys and St Thomas' hospital. He has a PhD from University College London (UCL) into focal therapy for newly diagnosed prostate cancer and cancer that has recurred after previous radiotherapy. He has helped design and deliver multiple clinical trials for primary, metastatic and radio-recurrent prostate cancer and is currently part of the imperial prostate (IP) group at Imperial College London (ICL).He has been an advocate for collaborative and also trainee led research and previously spent five years as vice chair of the British Urology Researchers in Surgical Training (BURST) research collaborative. Expertise Raised PSA, investigations for prostate cancer, MRI image-fusion targeted prostate biopsies, robotic radical prostatectomy, focal therapy, high intensity focused ultrasound, cryotherapy, enlarged prostate, benign prostate hyperplasia, Rezum water vapour therapy. Research & publications Light A, Ahmed HU, Shah TT, 2022, The unclear role of PET-CT in localized radiorecurrent prostate cancer COMMENT, Nature Reviews Urology, ISSN:1759-4812 Clement KD, Light A, Asif A, et al., 2022, A BURST-BAUS consensus document for best practice in the conduct of scrotal exploration for suspected testicular torsion: the Finding Consensus for Orchidopexy in Torsion (FIX-IT) study, Bju International, ISSN:1464-4096 Gao C, Peters M, Kurver P, et al., 2022, Nomogram predicting the probability of spontaneous stone passage in patients presenting with acute ureteric colic., Bju Int Khadhouri S, Gallagher KM, MacKenzie KR, et al., 2022, Developing a Diagnostic Multivariable Prediction Model for Urinary Tract Cancer in Patients Referred with Haematuria: Results from the IDENTIFY Collaborative Study., Eur Urol Focus Shah TT, Kanthabalan A, Otieno M, et al., 2022, Magnetic Resonance Imaging and Targeted Biopsies Compared to Transperineal Mapping Biopsies Before Focal Ablation in Localised and Metastatic Recurrent Prostate Cancer After Radiotherapy, European Urology, Vol:81, ISSN:0302-2838, Pages:598-605 Reddy D, Peters M, Shah TT, van Son M, et al., 2022, Cancer Control Outcomes Following Focal Therapy Using High-intensity Focused Ultrasound in 1379 Men with Nonmetastatic Prostate Cancer: A Multi-institute 15-year Experience., Eur Urol, Vol: 81, Pages: 407-413 Grey ADR, Scott R, Shah B, et al., 2022, Multiparametric ultrasound versus multiparametric MRI to diagnose prostate cancer (CADMUS): a prospective, multicentre, paired-cohort, confirmatory study, LANCET ONCOLOGY, Vol: 23, Pages: 428-438, ISSN: 1470-2045 Shah TT, Cathcart P, 2021, Surgical Volume Is Important for Radical Prostatectomy, but Now We Need to Move Beyond Volume as a Proxy for Quality, EUROPEAN UROLOGY, Vol: 80, Pages: 546-548, ISSN: 0302-2838 Shah TT, Reddy D, Peters M, et al., 2021, Focal therapy compared to radical prostatectomy for non- metastatic prostate cancer: a propensity score-matched study, PROSTATE CANCER AND PROSTATIC DISEASES, Vol: 24, Pages: 567-574, ISSN: 1365-7852

GIANVITO CANDITA CURRICULUM VITAE Date of birth / 16/10/1994 Age / 30 Place of birth / CEGLIE MESSAPICA (BR) ACADEMIC STUDIES Nationality/ citizenship / Italy Via San Paolo, 50, 56125 PISA (PI) Via Pietro Nenni, 2, 72021 FRANCAVILLA FONTANA (BR) SPECIALISATION SCHOOL Università di PISA Driving licence / B / Car available 2021 ‐ 2025 Radiodiagnostica ID/5036427 updated on 26/03/25 Dissertation/thesis title: Long-term results of microwave ablation in the treatment of early-stage HCC | Thesis supervisor: Prof.sa Laura  Crocetti gianvito.candita@gmail.com  +39 3493050399 Age at graduation: 30 | Official duration: 4 years Final degree mark: 110/110 cum laude Graduation date: 27/01/2025 FOREIGN LANGUAGE SKILLS *ALTA FORMAZIONE Università di PISA 2019 ‐ 2021 Ruolo delle terapie endovascolari nel trattamento del MOTHER TONGUE(S): Italian colangiocarcinoma intraepatico e delle altre lesioni neoplastiche epatiche Age at graduation: 26 | Official duration: 16 months ENGLISH B2 B2 B2 B2 B2 Graduation date: 25/01/2021 GOOD MASTER'S DEGREE Università di PISA 2013 ‐ 2019 Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in EXPECTATIONS AND FEATURES OF THE CERTIFIED TITLE Medicina e Chirurgia DESIRED JOB Medicine and Surgery LM-41 - 2nd level degree in Medicine and surgery INTENTION TO CONTINUE STUDIES: Yes / Dissertation/thesis title: TARE of intrahepatic cholangiocarcinoma: Post-degree specialisation school an Italian multicentric study | Thesis supervisor: CROCETTI ECONOMIC SECTOR: 1 healthcare LAURA|CARAMELLA DAVIDE CAREER FIELD: 1 Quality and security Age at graduation: 25 | Official duration: 6 years PREFERRED DISTRICT TO WORK IN: 1 PISA Final degree mark: 110/110 cum laude / 2 LIVORNO Graduation date: 26/10/2019 AVAILABILITY FOR BUSINESS TRAVELS: Yes, but not often SCIENTIFIC CERTIFICATE Scientific High School AVAILABILITY TO RELOCATE ABROAD: FRANCAVILLA FONTANA F. RIBEZZO - FRANCAVILLA FONTA , FRANCAVILLA FONTANA () Yes, even in non-European countries 2013 School-leaving examination mark: 100/100 cum laude Kind of secondary school diploma: Italian secondary school diploma OTHER POSTGRADUATE STUDIES STUDENT GRANT Interventional treatment of hepatic malignancies 2019 ‐ 2020 Università di PISA Duration: 12 months PROFESSIONAL ACCOLADES AND AWARDS AWARD / SCOLARSHIP Certificate of merit ECIO 2024 2024 Long-term results of percutaneous microwave ablation for very- early- and early-stage HCC ENROLLMENT IN THE Ordine dei Medici Chirurghi e Odontoiatri di Pisa PROFESSIONAL REGISTER 24/03/2020 STATE EXAMINATION Esame di stato per l'abilitazione alla professione medica 2020 CONFERENCES AND SEMINARS CONVENTIONS ECIO 2024 , Palma de Maiorca 2024 CONVENTIONS CIRSE 2023 , Copenhagen 01/09/2023 CONVENTIONS ET 2023 , Valencia 01/06/2023 CONFERENCES XVIII Campus in interventional Radiology , Pisa 01/04/2023 CONVENTIONS ECR 2022 , Wien 01/07/2022 CONFERENCES XVII Campus in Interventional Radiology 01/02/2022 CONVENTIONS ICIR 2021 , Florence 01/11/2021 CONVENTIONS SIRM 2021 , Rimini 01/10/2021 CONVENTIONS XVI Campus in Interventional Radiology 01/02/2021 CONFERENCES XV Campus in Interventional Radiology , Pisa 10/02/2020 PUBLICATIONS CONFERENCE PROCEEDINGS Candita G, Bozzi E, Cioni R, Crocetti L, Neri E, Long-term results of 2024 percutaneous microwave ablation for very-early- and early-stage HCC CONFERENCE PROCEEDINGS Candita G, Trans-Arterial Embolization of Renal Malignancies: case 2024 series SIO 24, Los Angeles JOURNAL ARTICLES Crocetti L, Bozzi E, Scalise P, Candita G, Cioni R, Thermal ablation of 2023 hepatocellular carcinoma Review: Journal of Medical Imaging and Radiation Oncology JOURNAL ARTICLES Gianvito Candita,Sara Rossi,Karolina Cwiklinska, Salvatore Claudio 2023 Fanni,Dania Cioni,Riccardo Lencioni andEmanuele Neri, Imaging Diagnosis of Hepatocellular Carcinoma: A State-of-the-Art Review Review: Diagnostics CONFERENCE PROCEEDINGS Candita G, Perrone O, Cioni R, Crocetti L, Neri E, Percutaneous 2023 Cryoablation of Renal Tumors: the role of intravascular embolization ET 2023, Valencia CONFERENCE PROCEEDINGS Candita G, Ambrosini I, Cioni R, Crocetti L, Neri E, CT-Guided 2023 Cryoablation of Renal Tumors CIRSE 23, Copenhagen CONFERENCE PROCEEDINGS Candita G, Radiogenomics: applications in primary liver cancer 2023 Pisa 2023 JOURNAL ARTICLES Dania Cioni, Michela Gabelloni, Andrea Sanguinetti, Laura De Rosa, 2022 Giacomo Aringhieri, Rachele Tintori, Gianvito Candita, Maria Febi, Francesco Faita,Riccardo Lencioni, Emanuele Neri, A New SteatoScore in the Evaluation of Non-Alcoholic Liver Disease in Oncologic Patients Review: Frontiers CONFERENCE PROCEEDINGS Candita G, Guarino S, Chiellini M, Goddi A, Cioni D, Neri E, CT and 2022 MR imaging of chemotherapy-associated liver injuries ECR 2022, Vienna CONFERENCE PROCEEDINGS Candita G, Ambrosini I, Spina N, Goddi A, Chiellini M, Cioni D, Neri E, 2022 Imaging Biomarkers in Diffuse Liver Disease CONFERENCE PROCEEDINGS Candita G, Chiellini M, Goddi A, Marchini M, Mattii M, Campani D, De 2022 Simone P, Cioni D, Neri E, Gadoxetic-Acid MRI in cirrhotic patients: radiologic-pathologic correlation in nodules without arterial enhancement and hepatobiliary hypointense pattern ECR 2022, Vienna CONFERENCE PROCEEDINGS Candita G, Rossi PC, Spina N, Marchini M, Cioni D, Neri E, Imaging 2022 Findings after Pancreatic Transplantation ECR 2022, Vienna JOURNAL ARTICLES Mosconi C, Crocetti L, Bruno A, Candita C, Cappelli A, Perrone O, 2020 Golfieri R, Scar Pregnancy and Extrauterine Implants Review: Seminars in Ultrasound, CT and MRI Publisher: Elsevier www.sciencedirect.com/science/article/abs/pii/S08… JOURNAL ARTICLES Gianvito CANDITA, Alessandro MARCUCCI, Chiara BOCCACCIO, Ilaria 2020 CARAMELLA, Embolization of hemorrhagic lymphangioleiomyomatotis-associated angiomyolipoma Review: Journal of Radiological Review

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